Photo of a filled syringe in which air bubbles float in the clear liquid.

Pharma

Inspection: Searching for air bubbles

Until recently, inspection cameras were unable to distinguish between harmless air bubbles and harmful foreign bodies in syringes and ampoules. An innovation from the Körber Business Area Pharma now immediately recognizes the difference between the two, and thus offers extensive benefits to the pharmaceutical industry.

Air bubbles are a serious matter for Werner Halbinger. “I’ve declared war on them,” he says. That’s because “they cause all kinds of problems” for him as an image-processing and laboratory engineer at the Körber Business Area Pharma, not to mention the company’s customers. The Business Area Pharma offers its Seidenader Solutions high-tech machines that inspect syringes, ampoules, and vials of various sizes in order to detect foreign particles or production defects.

Different inspection techniques are used depending on the product and receptacle in question. Most of the products tested are clear liquids in transparent and colorless glass receptacles, which undergo stringent quality assurance screenings. Anything that throws a shadow could be a foreign body but that doesn’t necessarily have to be the case. “Unfortunately, air bubbles are also registered as shadows by the detectors,” Halbinger explains. Such bubbles used to present a major challenge to Halbinger, his colleagues, and customers throughout the entire pharmaceutical industry.

Portrait photo of an engineer standing in front of a machine
The engineer Werner Halbinger has been working at Körber Business Area Pharma for twelve years on the detection of foreign bodies and air bubbles in pharmaceutical products.

Safety is the top priority

It was often difficult to clearly distinguish between harmless bubbles and problematic particles. During high-speed inspections you can’t simply wait until the unidentified objects sink to the bottom of a receptacle and thus become clearly identifiable as foreign bodies. For this reason, all products in which image-processing software detected a shadow during screening were rejected. Safety is the top priority, after all — and also the central promise to Körber’s customers.

These rejects are just plain annoying in the case of some medications and other medical products such as distilled water or vitamin solutions that are manufactured in large quantities. They are also a key cost driver for manufacturers of expensive active ingredients, especially biopharmaceuticals. Typical examples are cancer medications, vaccines against infectious diseases, and drugs that slow the progress of multiple sclerosis. Substantial savings could be achieved by preventing the destruction of even a small portion of the syringes, ampoules, and vials containing solutions of synthesized molecules that are often difficult and costly to manufacture.

Long before Halbinger discovered a possible approach to solving the bubble/foreign-substance mimicry problem, he and many other engineers worldwide looked for ways to minimize the number of rejects. The approaches explored here focused on preventing bubbles from forming at all, or else ensuring that those that did could be removed. Many of the inspection-related innovations did in fact lead to a steady decline in reject rates — but that still didn’t solve the problem.

The challenges Halbinger faced were therefore by no means minor when a customer requested that a new feasibility study be performed. Halbinger took test receptacles into his laboratory and began experimenting with polarization filters that raised contrast levels. He also experimented with color filters and a color camera. He kept on building makeshift apertures out of black cardboard and worked with different distances, filters, and sensitivity settings for image recognition software. “I wanted to take advantage of the fact that the air bubbles behave like optical lenses under certain conditions,” Halbinger, an optical expert himself, explains. Halbinger understood that his “enemies” were transparent spherical objects.

lAir bubbles behave like optical lenses under certain conditions.r

Werner Halbinger, image-processing and laboratory engineer for inspections at the Körber Business Area Pharma

Solution with a lens

At some point Halbinger noticed that the red-green-blue (RGB) pattern of the background light used for screening was being reflected in a very big air bubble. “Interesting,” he thought to himself. He then continued his experiments, changed settings, and kept observing how the light pattern in the bubble behaved. And even though he still couldn’t clearly detect air bubbles, especially very small ones, he nevertheless couldn’t get what he had observed out of his mind.

Ultimately, it was a Fresnel lens that enabled him to achieve the breakthrough he had long been waiting for. Such lenses are used to raise the contrast in error detection processes. In the beam path that is focused by the lens, even relatively small particles stand out significantly from the background, which makes them clearer to identify. In order to examine the properties of the Fresnel lens, Halbinger placed it in front of his computer screen. He then used a graphics program to draw in the colors red, green, and blue. 

There they were — regular patterns. “This looks promising; the same thing has got to work with air bubbles too!” he thought. Shortly thereafter, it was clear that this was indeed the case. When illuminated with RGB light through a Fresnel lens, air bubbles always betrayed their presence with a characteristic pattern — red at the top, green in the middle, and blue at the bottom. Just as importantly, optically transparent particles — the classic example is glass — displayed either no color pattern, random color patterns, or a pattern opposite to that produced by the air bubbles. These effects are caused by differences between the refractive properties of air bubbles and those of particles made of solid transparent materials.

Photo of an engineer in a laboratory on a computer next to a set of measuring instruments
Werner Halbinger spends most of his working day in the laboratory where Bubble-X was created.

“It took me a second to understand what Werner had done after he showed me — but then I immediately realized how much potential his discovery offered,” says Halbinger’s boss, Andreas Böhme, Manager Vision Engineering for Inspection Solutions at Körber’s Business Area Pharma. Böhme then began to consider just what could be achieved with such a technology. He also understood that they needed to figure out how to install a functioning system in a machine. As Böhme well knew, even the best idea only accounts for 10 to 20 percent of the total development process: “The rest is implementation.”

Böhme, Halbinger, and many other colleagues did exactly that. Today the patent has long since been registered — and Bubble-X is doing very well on the market. Indeed, several pharmaceutical companies have already ordered the first machines equipped with this innovative inspection technology. “There’s a huge amount of interest when I present it at conferences,” says Sales Director Christian Scherer. “We’ve acquired many new customers over the last few years especially, and one of the main reasons for this is definitely our expertise in technical innovation.”

That’s how small the air bubbles are that Bubble-X can now reliably distinguish from all types of foreign body. Halbinger is already working on ways to detect even tinier air bubbles.

To ensure that this remains the case, Halbinger has already identified a new “enemy,” which is basically another version of the old one. The issue here involves the fact that Bubble-X reliably detects air bubbles down to a size of 200 micrometers. This figure will gradually decrease to 100 micrometers over the next few years as camera resolutions and image-processing systems improve. After that, however, you enter into the realm of micro-bubbles. “That will be difficult, but those micro-bubbles are already on my list,” says Halbinger.

 

How Bubble-X works

Three sources of light (red, green, and blue — RGB lighting) are arranged in such a manner that the green beam in the center can pass straight through the convex lens (1) and thus always fall on the detector camera (3). The lens refracts the red and blue beams in a way that ensures they pass by the camera very closely when there is no fault. The three most common cases:

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